Introduction: Nowadays, we witness the development of computerized healthcare information systems, evidence-based medicine ,and e-learning approach at Medical Universities. Thus, medical students need to have familiarity with computer skills and information technology. The aim of this study was to survey computer literacy in students of general medicine at Ahvaz University of Medical Sciences.

  Methods: This study was observational ,cross-sectional in nature. The study was conducted in the academic year of 2009-2010 .The sample population consisted of 243 medical, pharmacy and dentistry students. A questionnaire was used for collecting data which were then analysed by SPSS using descriptive statistics..

  Results: The results showed that, students' familiarity with computers were low (35%). The most familiarity with computers were the ability to use it in managing files (48%), and the lowest was related to the ability to manage the Windows operating system (19%). Familiarity to use Power Point rated the highest among the other skills (75%), to use Access was the lowest (9%).The students familiarity with the Internet and theWeb were (39%). Students used less advanced methods for searching the information on the Internet. Overall,

  male students had more computer literacy than female student.

  Discussion: The students’ familiarity with computer literacy was not satisfactory. Therefore, it is necessary to plan educational programs for computer literacy skills at Ahvaz Jundishapur University of Medical Sciences.