Introduction: Researches showed the effective role of applying the hospital information systems (HIS) in upgrading quality of the curative care services, increasing satisfactions, and improving treatment economy. Due to the necessities of the HIS development and the important role of managers knowledge and attitudes, present study carried out to achieve the level of Golestan curative centers (province) managers knowledge and attitudes in 2006. 

Methods: Present study is a cross-sectional descriptive study, has been done on 73 people of the Golestan curative centers managers who agreed to participate in this study in the year 2006.Avalid and reliable questionnaire have been sent for each manager. After completing the questionnaire, collected data analyzed by SPSS software. Results: Our research findings showed that 59.3% of managers had average knowledge, and 95.1% had a positive attitude about the HIS. Maximum knowledge scores belonged to the medical records staffs, and minimum knowledge scores to operation theaters and hospital officers. Maximum level of the positive attitude found for laboratories staffs and minimum to finance and operation theaters department.

Conclusions: Due to the average levels of Golestan curative centers managers knowledge and attitudes about HIS, to improve HIS usage at all different departments, to hold the training courses to improving the level of knowledge is necessary.