Introduction: Expert systems are computer programs that have been designed aimed to make available personnel skills, for non-specialists. These programs are trying to model thinking to simulate human performance, and make correlation between performances of individual experts and software. Nowadays various expert systems have been presented in medical sciences. In diagnosis and treatment of blood cancer patients quickly acts are very influential. But sometimes access to specialists for patients and hence design a system based on knowledge to provide a specialist diagnosis and treatment is important. This make to patients, timely offers..

Methods: This article presents an expert system for diagnosis of leukemia using VP-expert shell. That knowledge has been offer rules of knowledge base system for diagnosis and treatment.

Results: In this paper, we shown that the absence of experts, using intelligent software can be relatively provide a reliable diagnosis and treatment methods.

Conclusion: The use of intelligent systems and semi-intelligent expert systems such as decision support systems can provide for. However, currently experts cannot be replaced by systems.