Introduction: Managers personality differences can be source of organizational creativity or inevitable problems. Which are effective factors in managers' behavior, decisions and behaviors. Managers who are apathetic to these differences, they can’t often achieve to organizational and individual goals. This research is about studying staff managers of Qom University of Medical Sciences (QUMS) based on Five Factor Model of Personality (Big-5).

Methods: This study is a descriptive - applied research. Population includes 31 staff managers of QUMS whom are selected based on stratified random sampling method. Research instrument is a researcher made Five factors model of Personality, and some management professors. In order to data analyzing ,τ test and Friedman Test by using SPSS software.

Results: The mean of Neuroticism in study population is less than average, and the means of other four dimensions includes extroversion, conciseness, agreeable, Openness, is higher than average. The highest mean is related to Conscientiousness and the lowest one is Neuroticism. Friedman rank test show that there is a meaningful difference between mean ranks. Neuroticism is the lowest one. 

Conclusion: Manageress's five factors personality fall in a desirable level.