Objective: To study hospital infection control system (organization and operations) at hospitals affiliated with Shiraz University of Medical Sciences and to provide guidlines.

Methods: The study was descriptive - analytical and cross-sectional in nature. Hospital managers, nurses, control committee staff of the Central Infection Control Commission of Fars province comprised the subjects of the study. Data was collected by questionnaires, interviews, and observations.

Finding(s): A low percentage of nurses (15.38%) were in charge of infection control and the rest (84.62%) were involved with other activities. Nurses scored the highest (61.53) in terms of their roles in infection control, and hospital managers ranked the second (53.84).

 Conclusion(s): Considering the crucial role hospital infection control plays, necessary workforce, including enviornment health experts and epidemiologists should be employed.