Introduction: Users of Hospital Information Systems use these systems, round o`clock and as such perceive their problems better than others. Investigating views of users are very critical in development of performance of the systems and should be effective in their development. The aim of this study was to investigate the users' views about Hospital Information System in teaching hospitals (Mashhad University of Medical Sciences).

Methods: This is an applied research with descriptive cross-sectional method. The sample subjects are recruiting through convenience sampling method. Three sectional valid and reliable questionnaires designed for data gathering consisting of: user interaction, quality of system, and quality of information. SPSS software was used for data analysis.

Results: Our findings showed that there is some slight satisfaction of 67.5% of users of the quality of function, 57.5% of quality performance, and 53.2% of quality information of system. Totally most users (70%) were slightly satisfied with hospital information systems.

 Conclusion: According to the study findings there are some problems in hospital information systems of Mashhad teaching hospitals. These problems consist of performance incompatibility between user needs and system which leads to has decrease of satisfaction of users to the system.