Introduction: Contrary to industrial economy, in knowledge economy, knowledge or intellectual capital plays a more significant role in achieving competitive advantage and attaining organizational goals compared with other assets. The aim of the current paper is to study the effect of intellectual capital on knowledge management processes influenced by the organizational culture in Mazandaran University of Medical Sciences.

Methods: The statistical population included all the university staff (total number = 230). The number of the participants who received the questionnaires was finally 183. The study was descriptive, and correlational which was used to collect the data; moreover, Bontis’s intellectual capital questionnaire (42 questions) and Lawson’s knowledge management questionnaire (24 questions) were exploited. The validity and reliability of questionnaires were firstly dermined.

Results: The results of statistical hypothesis testing based on SMART PLS 3.2.4 as well as those of test statistics (t) and path coefficients (ß) showed that intellectual capital had a positive and effective influence on knowledge managements steps including creating, receiving, saving, organizing, publishing and applying knowledge.

Conclusion: Organizations fully understood that they should pay more attention to intellectual capital and knowledge to guarantee surviving and effective activities. In other words, identification, development, and empowerment are some of the main features of organization in creating, sharing and applying organizational knowledge which can increase the knowledge base activities and improving knowledge management strategies.