Introduction: Nowadays, all the areas of human knowledge are affected by informatics’ knowledge and information technology. Health organizations and centers also need these technologies due to the vast variety of information. So the result of such a kind of knowledge is a tool named hospital information system (HIS). This research attempts to fill this gap and present a complete conceptual framework to evaluate HIS by means of introducing indexes and their priority.
Methods: Based on literature review, initial model of evaluating main dimensions and indexes of each dimension were introduced. These indexes were classified into different questions and a related questionnaire was published between 100 staff (users, managers and authorities of HIS) of different departments of educational hospitals of Qazvin city. The data gathered were analyzed using first and second order of factor analysis.
 Results: The result of the two orders of analysis revealed that all indexes are acceptable according to loading factor and T value. All fit indices were suitable, too.
 Conclusion: The results indicate that organizational, humanity and technical dimensions are three main dimensions of evaluation, and organizational structure, goals and strategies, cost-benefit analysis and clinical effects are indexes of organizational dimension. User Satisfaction, User Acceptance, and being familiar with ICT are main indexes of humanity dimension. Finally, system quality, information quality and information security are main indexes of technical dimension.