Introduction: The World Health Organization defines health as "not merely the absence of disease or infirmity"-but as a concept that incorporates notions of well-being or wellness in all areas of life (physical, mental, emotional, social, spiritual). Quality of life (QOL) reflects the differences, the gaps, between the hopes and expectations of person and their present experience.

 Methods: This was a cross- sectional research, done in 2004 to study staff QOL in Health Insurance organization(HIO). The research population was 684 from and The Head Quarter in HIO. The sample population was 510 person (334 person Tehran's main branch and 176 Person in the Head Quarter), whose QOL was analysed with respect to sex, marital status and educational level. A pilot study was done to determine The reliability of QOL questionnaire with sample size of 50 (alpha 0.84). Data analysis taken from, frequency tables was done calculating the means of the data, and using independent T-Test, One-way and Multi-way analysis of variances, and Analysis of Covariance.

Findings: The mean scores of QOL in Tehran's main branch and the Head Quarter were 145.36 and 149.8, respectively, which indicated a significant difference (P-Value = 0.08 and a= 0.05). Comparison of the QOL in the work place, work place and job, work place and income revealed a significant difference between them at a= 0.05 (P-Value < 0.05). The result didn't show a significant difference between the mean scores of QOL and other independent variables such as: sex, marital status and age group.

Conclusion:Although, Staff QOL was evaluated at a good level, they had a different QOL with respect to work place, kind of job and income. Therefore in order to enhance staff QOL, decisions should be taken to improve their life and job conditions.